Ocirculation and subsequent wound healing The role of anesthetic technique in postoperative wound repair is not well studied. However, several lines of retrospective data analyses of outcomes after cancer surgery suggest that anesthetic technique can influence mechanisms that are relevant to tissue repair R1503MedChemExpress Pamapimod processes98. Wound healing and cancer progression share several pathways: cellular proliferation and migration are accelerated; the extracellular matrix undergoes greater turnover; and neovascularization is enhanced. These effects are mediated by a surge of inflammatory mediators, cytokines, and growth factors that are common to both wound repair and cancer. Although the endpoints in these studies were cancer recurrence or metastases, the subsequent changes in growth factor levels or activity of matrix degrading MMPs99, 100 are likely relevant to tissue healing. It is notable, however, that the groups studied differed not only in the use of inhalational versus intravenous agents, but in the use of other variables such as the amount of opiates used to control pain. Each of these components has collateral effects including changes in regional blood flow and the effective microcirculation. Nonetheless, the underlying mechanisms that influence cancer surgery outcomes should be noted when examining determinants of post-operative wound healing. IIID1. The effect of anesthetic technique: general versus regional–Although clinical and theoretical perceptions often advocate for regional anesthesia rather than general anesthesia in older patients, there is no difference in various outcomes measures101, 102. Comparisons are difficult: for example, in a retrospective analysis neuroaxial anesthesia (epidural or spinal anesthesia) for total hip or knee replacement was associated with a lower risk of SSI than general anesthesia, but the general anesthesia group was older with more comorbidities making it difficult to form definitive recommendations103.Anesthesiology. Author manuscript; S28463 biological activity available in PMC 2015 March 01.Bentov and ReedPageEffects of anesthesia on physiologic variables relevant to the microcirculation and subsequent wound repair have been examined and will be discussed here. For example, general anesthesia causes vasodilation by direct effects on the peripheral microcirculation104 and indirectly by central inhibition of vasoconstriction105. Thoracic epidural anesthesia increases peripheral tissue oxygen tension, even outside the dermatome affected by the block106. Core hypothermia develops equally under general and epidural anesthesia due to vasodilation in the skin’s microcirculation and loss of thermoregulation. During epidural anesthesia, skin thermoregulation in the region affected by the epidural (lower body) is reduced independent of patient age. Not surprisingly, young patients are better able than older patients to maintain skin thermoregulation in the regions not affected by epidural anesthesia107. Administration of typical doses of volatile or intravenous agents does not suppress the contribution of the endocrine response to the microcirculation108. In contrast, regional anesthesia (most notably neuroaxial blockade) blunts the endocrine stress response to surgery109. Continuous lumbar plexus and sciatic nerve blocks did not affect cortisol levels, but attenuated the postoperative inflammatory response (lower C-reactive protein)110. In a study of regional block after knee arthroplasty, clinical signs of inflammation were reduced.Ocirculation and subsequent wound healing The role of anesthetic technique in postoperative wound repair is not well studied. However, several lines of retrospective data analyses of outcomes after cancer surgery suggest that anesthetic technique can influence mechanisms that are relevant to tissue repair processes98. Wound healing and cancer progression share several pathways: cellular proliferation and migration are accelerated; the extracellular matrix undergoes greater turnover; and neovascularization is enhanced. These effects are mediated by a surge of inflammatory mediators, cytokines, and growth factors that are common to both wound repair and cancer. Although the endpoints in these studies were cancer recurrence or metastases, the subsequent changes in growth factor levels or activity of matrix degrading MMPs99, 100 are likely relevant to tissue healing. It is notable, however, that the groups studied differed not only in the use of inhalational versus intravenous agents, but in the use of other variables such as the amount of opiates used to control pain. Each of these components has collateral effects including changes in regional blood flow and the effective microcirculation. Nonetheless, the underlying mechanisms that influence cancer surgery outcomes should be noted when examining determinants of post-operative wound healing. IIID1. The effect of anesthetic technique: general versus regional–Although clinical and theoretical perceptions often advocate for regional anesthesia rather than general anesthesia in older patients, there is no difference in various outcomes measures101, 102. Comparisons are difficult: for example, in a retrospective analysis neuroaxial anesthesia (epidural or spinal anesthesia) for total hip or knee replacement was associated with a lower risk of SSI than general anesthesia, but the general anesthesia group was older with more comorbidities making it difficult to form definitive recommendations103.Anesthesiology. Author manuscript; available in PMC 2015 March 01.Bentov and ReedPageEffects of anesthesia on physiologic variables relevant to the microcirculation and subsequent wound repair have been examined and will be discussed here. For example, general anesthesia causes vasodilation by direct effects on the peripheral microcirculation104 and indirectly by central inhibition of vasoconstriction105. Thoracic epidural anesthesia increases peripheral tissue oxygen tension, even outside the dermatome affected by the block106. Core hypothermia develops equally under general and epidural anesthesia due to vasodilation in the skin’s microcirculation and loss of thermoregulation. During epidural anesthesia, skin thermoregulation in the region affected by the epidural (lower body) is reduced independent of patient age. Not surprisingly, young patients are better able than older patients to maintain skin thermoregulation in the regions not affected by epidural anesthesia107. Administration of typical doses of volatile or intravenous agents does not suppress the contribution of the endocrine response to the microcirculation108. In contrast, regional anesthesia (most notably neuroaxial blockade) blunts the endocrine stress response to surgery109. Continuous lumbar plexus and sciatic nerve blocks did not affect cortisol levels, but attenuated the postoperative inflammatory response (lower C-reactive protein)110. In a study of regional block after knee arthroplasty, clinical signs of inflammation were reduced.
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