Product Name :
CCT251455
Description:
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.
CAS:
1400284-80-1
Molecular Weight:
503.98
Formula:
C26H26ClN7O2
Chemical Name:
tert-butyl 6-[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
Smiles :
CC(C)(C)OC(=O)N1C(=CC2C=NC(=CC1=2)NC1=CC=C(C=C1Cl)C1=CN=CN1C)C1C=NN(C)C=1
InChiKey:
BXKNUXDLZJPPBO-UHFFFAOYSA-N
InChi :
InChI=1S/C26H26ClN7O2/c1-26(2,3)36-25(35)34-21(18-12-30-33(5)14-18)9-17-11-29-24(10-22(17)34)31-20-7-6-16(8-19(20)27)23-13-28-15-32(23)4/h6-15H,1-5H3,(H,29,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambien…
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Insulin (human) Epigenetics
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.Tetraconazole Fungal |Product information|CAS Number: 1400284-80-1|Molecular Weight: 503.98|Formula: C26H26ClN7O2|Chemical Name: tert-butyl 6-[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate|Smiles: CC(C)(C)OC(=O)N1C(=CC2C=NC(=CC1=2)NC1=CC=C(C=C1Cl)C1=CN=CN1C)C1C=NN(C)C=1|InChiKey: BXKNUXDLZJPPBO-UHFFFAOYSA-N|InChi: InChI=1S/C26H26ClN7O2/c1-26(2,3)36-25(35)34-21(18-12-30-33(5)14-18)9-17-11-29-24(10-22(17)34)31-20-7-6-16(8-19(20)27)23-13-28-15-32(23)4/h6-15H,1-5H3,(H,29,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: 10 mM in DMSO|Shipping Condition: Shipped under ambien…|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CCT251455 is a highly potent inhibitor of MPS1 that demonstrates high selectivity versus kinases tested in a broad kinome profiling panel.PMID:32362203 CCT251455 inhibits P-MPS1 with an IC50 of 0.04 μM in cell-based assay and has a GI50 of 0.16 μM.|In Vivo:|CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration.|References:|Naud S, et al. Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem. 2013 Dec 27;56(24):10045-65.Products are for research use only. Not for human use.|
