Product Name :
MC-VC-PAB-Tubulysin M
Description:
MC-vc-PAB-Tubulysin M consists a cleavable ADC linker (MC-vc-PAB) and a cytotoxic tubulin inhibitor Tubulysin M (HY-N7053). Tubulysin M is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.
CAS:
1639939-56-2
Molecular Weight:
1312.57
Formula:
C66H93N11O15S
Chemical Name:
(2S,4R)-4-(2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-2-[(2R)-1-[(4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]-3-methylbutanamido]pentanamido]phenylmethoxy)carbonyl]piperidin-2-yl]formamido-N,3-dimethylpentanamido]-4-methylpentyl]-1,3-thiazol-4-ylformamido)-2-methyl-5-phenylpentanoic acid
Smiles :
CN([C@H](C[C@@H](OC(C)=O)C1=NC(=CS1)C(=O)N[C@@H](CC1C=CC=CC=1)C[C@H](C)C(O)=O)C(C)C)C(=O)[C@@H](NC(=O)[C@H]1CCCCN1C(=O)OCC1C=CC(=CC=1)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(C)C)[C@@H](C)CC
InChiKey:
RIMZNVUCGMFJGP-KCYCJFSYSA-N
InChi :
InChI=1S/C66H93N11O15S/c1-10-41(6)57(63(86)75(9)51(39(2)3)36-52(92-43(8)78)62-72-49(38-93-62)59(83)70-47(34-42(7)64(87)88)35-44-20-13-11-14-21-44)74-60(84)50-23-16-18-32-76(50)66(90)91-37-45-25-27-46(28-26-45)69-58(82)48(22-19-31-68-65(67)89)71-61(85)56(40(4)5)73-53(79)24-15-12-17-33-77-54(80)29-30-55(77)81/h11,13-14,20-21,25-30,38-42,47-48,50-52,56-57H,10,12,15-19,22-24,31-37H2,1-9H3,(H,69,82)(H,70,83)(H,71,85)(H,73,79)(H,74,84)(H,87,88)(H3,67,68,89)/t41-,42-,47+,48-,50+,51+,52+,56-,57-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Gemfibrozil custom synthesis
Shelf Life:
≥12 months if stored properly.Voxilaprevir Biological Activity
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MC-vc-PAB-Tubulysin M consists a cleavable ADC linker (MC-vc-PAB) and a cytotoxic tubulin inhibitor Tubulysin M (HY-N7053). Tubulysin M is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.|Product information|CAS Number: 1639939-56-2|Molecular Weight: 1312.57|Formula: C66H93N11O15S|Chemical Name: (2S,4R)-4-(2-[(1R,3R)-1-(acetyloxy)-3-[(2S,3S)-2-[(2R)-1-[(4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido]-3-methylbutanamido]pentanamido]phenylmethoxy)carbonyl]piperidin-2-yl]formamido-N,3-dimethylpentanamido]-4-methylpentyl]-1,3-thiazol-4-ylformamido)-2-methyl-5-phenylpentanoic acid|Smiles: CN([C@H](C[C@@H](OC(C)=O)C1=NC(=CS1)C(=O)N[C@@H](CC1C=CC=CC=1)C[C@H](C)C(O)=O)C(C)C)C(=O)[C@@H](NC(=O)[C@H]1CCCCN1C(=O)OCC1C=CC(=CC=1)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN1C(=O)C=CC1=O)C(C)C)[C@@H](C)CC|InChiKey: RIMZNVUCGMFJGP-KCYCJFSYSA-N|InChi: InChI=1S/C66H93N11O15S/c1-10-41(6)57(63(86)75(9)51(39(2)3)36-52(92-43(8)78)62-72-49(38-93-62)59(83)70-47(34-42(7)64(87)88)35-44-20-13-11-14-21-44)74-60(84)50-23-16-18-32-76(50)66(90)91-37-45-25-27-46(28-26-45)69-58(82)48(22-19-31-68-65(67)89)71-61(85)56(40(4)5)73-53(79)24-15-12-17-33-77-54(80)29-30-55(77)81/h11,13-14,20-21,25-30,38-42,47-48,50-52,56-57H,10,12,15-19,22-24,31-37H2,1-9H3,(H,69,82)(H,70,83)(H,71,85)(H,73,79)(H,74,84)(H,87,88)(H3,67,68,89)/t41-,42-,47+,48-,50+,51+,52+,56-,57-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33225751 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Wang Y, et al. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules. Mol Pharmacol. 2016 Feb;89(2):233-42.Products are for research use only. Not for human use.|
