Product Name :
CU-CPT-9a
Description:
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.
CAS:
2165340-32-7
Molecular Weight:
265.31
Formula:
C17H15NO2
Chemical Name:
4-(7-methoxyquinolin-4-yl)-2-methylphenol
Smiles :
CC1C=C(C=CC=1O)C1=CC=NC2=CC(=CC=C12)OC
InChiKey:
HNYBTVKYLVLWCB-UHFFFAOYSA-N
InChi :
InChI=1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.|Product information|CAS Number: 2165340-32-7|Molecular Weight: 265.31|Formula: C17H15NO2|Chemical Name: 4-(7-methoxyquinolin-4-yl)-2-methylphenol|Smiles: CC1C=C(C=CC=1O)C1=CC=NC2=CC(=CC=C12)OC|InChiKey: HNYBTVKYLVLWCB-UHFFFAOYSA-N|InChi: InChI=1S/C17H15NO2/c1-11-9-12(3-6-17(11)19)14-7-8-18-16-10-13(20-2)4-5-15(14)16/h3-10,19H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 135 mg/mL (508.84 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Anti-Mouse CD209b Antibody medchemexpress |Shelf Life: ≥12 months if stored properly.Phorbol 12-myristate 13-acetate In Vivo |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32822241 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases.|Products are for research use only. Not for human use.|
