Product Name :
EB-47
Description:
EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.
CAS:
366454-36-6
Molecular Weight:
537.53
Formula:
C24H27N9O6
Chemical Name:
2-4-[(2S, 3S, 4R, 5R)-5-(6-amino-9H-purin-9-yl)-3, 4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl-N-(1-oxo-2, 3-dihydro-1H-isoindol-4-yl)acetamide
Smiles :
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)NC2=CC=CC3=C2CNC3=O)CC1
InChiKey:
DDFLFKTXUWPNMV-UAKAABGRSA-N
InChi :
InChI=1S/C24H27N9O6/c25-20-16-21(28-10-27-20)33(11-29-16)24-18(36)17(35)19(39-24)23(38)32-6-4-31(5-7-32)9-15(34)30-14-3-1-2-12-13(14)8-26-22(12)37/h1-3,10-11,17-19,24,35-36H,4-9H2,(H,26,37)(H,30,34)(H2,25,27,28)/t17-,18+,19-,24+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.|Product information|CAS Number: 366454-36-6|Molecular Weight: 537.Tafasitamab Description 53|Formula: C24H27N9O6|Chemical Name: 2-4-[(2S, 3S, 4R, 5R)-5-(6-amino-9H-purin-9-yl)-3, 4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl-N-(1-oxo-2, 3-dihydro-1H-isoindol-4-yl)acetamide|Smiles: NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)NC2=CC=CC3=C2CNC3=O)CC1|InChiKey: DDFLFKTXUWPNMV-UAKAABGRSA-N|InChi: InChI=1S/C24H27N9O6/c25-20-16-21(28-10-27-20)33(11-29-16)24-18(36)17(35)19(39-24)23(38)32-6-4-31(5-7-32)9-15(34)30-14-3-1-2-12-13(14)8-26-22(12)37/h1-3,10-11,17-19,24,35-36H,4-9H2,(H,26,37)(H,30,34)(H2,25,27,28)/t17-,18+,19-,24+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.GCN2 modulator-1 Description |Shelf Life: ≥12 months if stored properly.PMID:32648236 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0 µM, respectively.|In Vivo:|EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation.|Products are for research use only. Not for human use.|
