H and promotes apoptosis in human lung Ombitasvir Autophagy Isophorone Purity & Documentation Cancer cell

H and promotes apoptosis in human lung Ombitasvir Autophagy Isophorone Purity & Documentation Cancer cell line A549. J Exp Clin Cancer Res 2010, 29:99?06. Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ: Klotho, an antisenescence associated gene, is often inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol 2011, 32:729?35. Lu L, Katsaros D, Wiley A, de la Longrais IA, Puopolo M, Yu H: Klotho expression in epithelial ovarian cancer and its association with insulinlike development components and illness progression. Cancer Invest 2008, 26:185?92. Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, Kuro-o M, Karlan B, Kaufman B, Koeffler HP, Rubinek T: Klotho: a tumor suppressor and a modulator of your IGF-1 and FGF pathways in human breast cancer. Oncogene 2008, 27:7094?0105. Abramovitz L, Rubinek T, Ligumsky H, Bose S, Barshack I, Avivi C, Kaufman B, Wolf I: KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. Clin Cancer Res 2011, 17:4254?266. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M: Suppression of aging in mice by the hormone Klotho. Science 2005, 309:1829?833. Kooijman R: Regulation of apoptosis by insulin-like growth issue (IGF)-I. Cytokine Growth Factor Rev 2006, 17:305?23. Yang S, Xiao X, Meng X, Leslie KK: A mechanism for synergy with combined mTOR and PI3 kinase inhibitors. PLoS One 2011, 6:e26343. Cheng Y, Qiu F, Ye YC, Guo ZM, Tashiro S, Onodera S, Ikejima T: Autophagy inhibits reactive oxygen species-mediated apoptosis through activating p38nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells. FEBS J 2009, 276:1291?306. Levine B, Yuan J: Autophagy in cell death: an innocent convict? J Clin Invest 2005, 115:2679?688. Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB: Development aspect regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120:237?48. Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, OgierDenis E: The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001, 276:35243?5246. Degtyarev M, De Mazi e A, Orr C, Lin J, Lee BB, Tien JY, Prior WW, van Dijk S, Wu H, Gray DC, Davis DP, Stern HM, Murray LJ, Hoeflich KP, Klumperman J, Friedman LS, Lin K: Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol 2008, 183:101?16. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M: FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007, 6:458?71. Zhang X, Mi J, Wetsel WC, Davidson C, Xiong X, Chen Q, Ellinwood EH, Lee TH: PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain location specificity. Biochem Biophys Res Commun 2006, 340:1144?150.Submit your subsequent manuscript to BioMed Central and take full advantage of:?Easy on-line submission ?Thorough peer evaluation ?No space constraints or colour figure charges ?Immediate publication on acceptancedoi:ten.1186/1475-2867-13-18 Cite this article as: Xie et al.: Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Interna.