(arachidonic acid and linoleic acid), -3 PUFAs (EPA, DPA, DHA, and alpha-linolenic acid), their metabolites,

(arachidonic acid and linoleic acid), -3 PUFAs (EPA, DPA, DHA, and alpha-linolenic acid), their metabolites, plus the function of monounsaturated fatty acids in oxidative tension andEdited and reviewed by: Nada A. Abumrad, Washington University in St. Louis, Usa Correspondence: Chunjiong Wang [email protected] Jun Yang [email protected] Xu Zhang [email protected] Specialty section: This article was submitted to Lipid and Fatty Acid Analysis, a section with the journal Frontiers in Physiology Received: 10 September 2021 Accepted: 01 November 2021 Published: 22 November 2021 Citation: Wang C, Yang J and Zhang X (2021) Editorial: The Part of Bioactive Lipids in Homeostasis and Pathology. Front. Physiol. 12:773632. doi: ten.3389/fphys.2021.Frontiers in Physiology | frontiersin.orgNovember 2021 | Volume 12 | ArticleWang et al.Editorial: The Function of Bioactive Lipids in Homeostasis and PathologyFIGURE 1 | Overview of the contributions incorporated beneath the Analysis Topic “Role of Bioactive Lipids in Homeostasis and pathology.” PUFA, polyunsaturated fatty acid; CyPGs, cyclopentenone prostaglandins; ARA, arachidonic acid; LA, linoleic acid; ALA, alpha-linolenic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; FA, fatty acid; HHcy, hyperhomocysteinemia; LPC, lysophosphatidylcholin; LPE, lysophosphatidylethanolamine; PI, phosphatidylinositol; Cer1P, ceramide-1-phosphate; Cer, ceramide; SMC, smooth muscle cell; DC, dendritic cell. See text for any brief description plus the reference of every contributing write-up.inflammation had been reviewed by Mazzocchi et al. Furthermore, this overview short article discussed the clinical CYP26 Inhibitor Gene ID studies performed with a variety of seed oils and marine animal-derived oils. This overview highlighted the truth that high heterogeneity in oil composition plays a considerable part in well being outcomes (Mazzocchi et al.). Moreover, as reported by Liu et al., the metabolite profiles of arachidonic acid and DHA are altered in higher iodide-intakeinduced hypothyroid offspring rats. Iodide intake adjustment plus 1,25(OH)2D3 supplementation ameliorated hypothyroid and metabolic disturbances together with enhanced serum EET and hydroxyeicosatetraenoic acid (HETE) levels (Liu et al.). The effects of bioactive lipids in the respiratory CXCR4 Inhibitor Compound system were also emphasized in this Investigation Subject. A clinical study reported alterations in serum glycerophospholipids within the acute exacerbation of chronic obstructive pulmonary illness (COPD) and several subtypes of COPD (Gai et al.). Sahanic et al. thoroughly reviewed bioactive lipid mediators in COVID-19 and influenza. They further promoted the current know-how concerning the mediator lipidome in severely impacted COVID-19 individuals. They accomplished this by investigating a publicly out there RNA-seq database of bronchoalveolar lavage cells (Sahanic et al.). The effects of sphingolipids on the cardiovascular method have been reported in a study write-up from Hua et al. Theauthors demonstrated that the myocardial sphingolipid profile was altered just after myocardial infarction injury. In particular, the ratio of ceramide-1-phosphate/ceramide was enhanced within the myocardial infarction-injured heart tissue with a greater ceramide kinase expression (Hua et al.). The function and effects of metabolic enzymes of fatty acids are a crucial topic inside the field of bioactive lipids. Cytochrome P450 omega-hydroxylase 4a14 (Cyp4a14), a homolog of human CYP4A hydroxylase, catalyzes arachidonic acid to